CPU Comparison
Intel Xeon 6746E vs Intel Xeon 6780E
A side-by-side comparison of specs, performance and value. The Intel Xeon 6746E is a 112-core server processor built on the Sierra Forest architecture, designed exclusively with efficiency cores (E-cores) to deliver exceptional core density and throughput for cloud-native, containerized, and heavily multi-threaded workloads.
The Bottom Line
Overview & Launch
Specifications Compared
Performance Compared
Productivity
Gaming
Virtualization
Efficiency
Specialized Performance
AI / ML
- No dedicated AI acceleration matrix like in P-core Xeons.
- CPU-based inference can leverage many cores for batch processing.
- On-die QAT accelerator can assist with AI-related compression/encryption.
- Supports Intel DL Boost (AVX2 VNNI) for CPU inference, but lacks specialized matrix engines.
- Typically paired with discrete accelerators (GPUs/DPUs) for heavier AI workloads.
- E-core architecture is best for inference latency across many small models, not training.
Content Creation
Gaming
- Lacks high single-core turbo frequencies.
- E-cores not optimized for low-latency gaming workloads.
- No integrated graphics.
- Not designed or marketed for gaming workloads.
- Single-core frequency is modest compared to client CPUs.
- Lacks integrated graphics; discrete GPU required.
Industry Impact
Best CPU by Use Case
Target Audience
Strengths & Weaknesses
Pros
- Unmatched core density (112 cores) in a single socket.
- Excellent energy efficiency for cloud throughput workloads.
- Integrated accelerators reduce need for discrete solutions.
- Massive I/O with 88 PCIe 5.0 lanes.
- Enables high consolidation ratios, saving rack space and power.
Cons
- Low base and turbo clock speeds limit single-thread performance.
- No Hyper-Threading, which may affect performance in some legacy applications.
- High cost per core compared to consumer or older Xeon platforms.
- Requires software optimized for many-core architectures.
- Limited to 2S scalability; not for extreme scale-up systems.
Pros
- 144 E-cores for high parallelism
- Eight-channel DDR5-6400 memory
- 88 PCIe 5.0 lanes for extensive I/O
- Built-in accelerators (QAT, DSA, DLB, IAA)
- Intel 3 process for better efficiency
- Supports up to 4 TB of memory
Cons
- No AVX-512 support limits some HPC workloads
- Modest boost clocks for latency-sensitive tasks
- 330 W TDP demands robust cooling
- No integrated graphics
- Multiplier locked; not for overclocking
Competitors & Alternatives
Intel Xeon 6746E
- AMD EPYC 9004 Series (e.g., EPYC 9654)Rival
Cloud/High-Density Server
- Intel Xeon 6700E Series (Other SKUs)Rival
Cloud/High-Density Server
- Ampere Altra MaxRival
Cloud/Arm-based Server
- Intel Xeon Scalable 5th Gen (Emerald Rapids)Rival
General Purpose Server
- AMD EPYC 8004 Series (Siena)Rival
Single-Socket Cloud Server
Higher core count (144 cores) for even greater density, if budget allows.
Compare head-to-head- Intel Xeon Platinum 8592+Alt
For workloads requiring strong single-thread performance and P-core features like AMX.
- AMD EPYC 9654Alt
Offers 96 cores with SMT (192 threads) and competitive performance per watt in cloud scenarios.
- Intel Xeon Gold 6430Alt
A balanced P-core Xeon for mixed workloads needing both single-thread speed and moderate core count.
- Intel Xeon w9-3495XAlt
A workstation-focused P-core Xeon with high clocks and unlocked multiplier for specialized tasks.
Intel Xeon 6780E
- AMD EPYC 9754 (Bergamo)Rival
Server
- AMD EPYC 9684X (Genoa-X)Rival
Server
Similar core count with lower TDP and different frequency profile.
Compare head-to-head- 5th Gen Intel Xeon ScalableAlt
P-core-based choice for higher per-core performance needs.
- AMD EPYC 9754Alt
Zen 4c-based high-core-count competitor optimized for cloud.
Our Verdict on Each
A paradigm-shifting Xeon processor that trades single-thread speed for unparalleled core density and efficiency, perfectly tailored for the modern cloud data center.
Best for: Building new cloud data center racks for containerized, microservices, or VDI workloads where core density and power efficiency are paramount.
Read the full reviewThe Xeon 6780E delivers exceptional core density and throughput for scale-out cloud and containerized workloads, but the lack of AVX-512 and modest clock speeds mean it is not optimized for compute-bound HPC or single-threaded tasks.
Best for: High-density cloud deployments and large-scale virtualization.
Read the full reviewFrequently Asked Questions
Which is better, Intel Xeon 6746E or Intel Xeon 6780E?
Based on our editorial ratings, the Intel Xeon 6746E comes out ahead with a score of 9/10. That said, the best choice depends on your workload — check the spec and performance breakdown above for gaming, productivity and efficiency differences.
Which is faster for gaming, Intel Xeon 6746E or Intel Xeon 6780E?
For gaming, the Intel Xeon 6746E leads with a gaming performance score of 30/100 among Intel Xeon 6746E and Intel Xeon 6780E.
Which uses less power?
The Intel Xeon 6746E has the lowest rated TDP. Power draw across these chips: Intel Xeon 6746E (250 W), Intel Xeon 6780E (330 W).
Do Intel Xeon 6746E and Intel Xeon 6780E use the same socket?
Yes — all of these CPUs use the FCLGA4710 socket, so they share compatible motherboards.
Which has more cores?
The Intel Xeon 6780E has the most cores. Core counts: Intel Xeon 6746E (112 cores), Intel Xeon 6780E (144 cores).